PrEP is a voluntary and temporary treatment, you can stop taking PrEP at any time and you can start taking it again. The decision to use or not to use PrEP depends on how you have sex (risky/safe), not necessarily on how much sex you have.

Taking PrEP daily

Daily PrEP is the most common form for people taking PrEP. It is as simple as taking one pill a day. Daily PrEP can also include taking PrEP for short periods of time, such as during a holiday period. PrEP can be taken with food, and at any time of the day. It is best to take PrEP at the same time each day so that it becomes part of a daily routine.

👉 ¡¡Once a day every day!! 👈

When starting PrEP, it takes at least 48 hours to reach high levels of protection against HIV.

When withdrawing PrEP, individuals should continue to use PrEP for four days after significant exposure.


Taking PrEP on demand

PrEP taken on demand is when you take PrEP during periods when you have sex. For it to work, you need to know in advance when you plan to have sex. You need to understand the dosing schedule and it is important that you do not skip doses. Otherwise, you may not be fully protected.

The on-demand dose of PrEP is as follows, a total of 4 tablets are taken:

  • 2 tablets 2 to 24 hours before sexual relations.
  • 1 tablet within 24 hours of first dose.
  • 1 tablet within 48 hours of the first dose.

This would prevent HIV infection in the majority of cases, with a 95% reduction in the risk of infection (compared to 99% of the daily pattern).


If a daily dose is missed, the level of protection against HIV may decrease. People who use PrEP correctly and consistently have higher levels of protection against HIV.

  • Taking 7 PrEP pills per week gives you 99% immunity and protection.
  • For people taking 4 PrEP pills per week, their estimated level of protection is 96%.
  • 2 PrEP pills per week means you are at high risk of contracting HIV, your estimated level of protection is 76%.

There are no studies on the level of protection from skipping doses with on-demand PrEP.